Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …

Novel experimental approaches such as fate-map** and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

The intestinal epithelium has a high turnover rate and constantly renews itself through
proliferation of intestinal crypt cells, which depends on insufficiently characterized signals …

Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Tissue-resident macrophages (M TR) have recently emerged as a key rheostat capable of
regulating the balance between organ health and disease. In most organs, ontogenetically …