Significance: Social and demographic changes have led to an increased prevalence of
loneliness and social isolation in modern society. Recent Advances: Population-based …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

In recent decades, cancer research has expanded exponentially beyond the study of
abnormally dividing cells to include complex and extensive heterotypic interactions between …

The peripheral autonomic nervous system (ANS) is known to regulate gene expression in
primary tumours and their surrounding microenvironment. Activation of the sympathetic …

Social isolation has been recognized as a major risk factor for morbidity and mortality in
humans for more than a quarter of a century. Although the focus of research has been on …

Highlights•Chronic stress activates a conserved transcriptional response to adversity
(CTRA).•The CTRA involves increased inflammation and decreased antiviral activity.•The …

Although we generally experience our bodies as being biologically stable across time and
situations, an emerging field of research is demonstrating that external social conditions …

Beta-adrenergic signaling has been found to regulate multiple cellular processes that
contribute to the initiation and progression of cancer, including inflammation, angiogenesis …

Health disparities (differences in health by socioeconomic groups) are a pressing issue in
our society. This article provides an overview of a multilevel approach that seeks to …

Different aspects of personal relationships including social integration, social support, and
social conflict have been related to inflammation. This article summarizes evidence linking …