Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

The intricate balance of immune reactions towards invading pathogens and immune
tolerance towards self is pivotal in preventing autoimmune diseases, with the thymus playing …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …

The thymus contains a diversity of dendritic cells (DCs) that exist in defined locations and
have different antigen-processing and-presenting features. This suggests that they play …

Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model
recapitulates both association and dissociation between pain and joint inflammation in RA …

The extent of central T cell tolerance is determined by the diversity of self-antigens that
develo** thymocytes 'see'on thymic antigen-presenting cells (APCs). Here, focusing on …

Over the last decade, multiple studies have investigated the heterogeneity of murine
conventional dendritic cells type 2 (cDC2s). However, their phenotypic similarity with …

The thymus is a crucial organ for the development of T cells. T cell progenitors first migrate
from the bone marrow into the thymus. During the journey to become a mature T cell …

Conventional dendritic cells (cDCs) are found in most tissues and play a key role in initiation
of immunity. cDCs require constant replenishment from progenitors called pre-cDCs that …

Autoimmune attack toward pancreatic β cells causes permanent loss of glucose
homeostasis in type 1 diabetes (T1D). Insulin secretory granules store and secrete insulin …