The assembly of just a single kinetochore at the centromere of each sister chromatid is
essential for accurate chromosome segregation during cell division. Surprisingly, despite …

The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

Background Centromeres are essential for chromosome segregation, yet their DNA
sequences evolve rapidly. In most animals and plants that have been studied, centromeres …

Centromeres are chromosomal elements that are both necessary and sufficient for
chromosome segregation. However, the puzzlingly broad range in centromere complexity …

Kinetochore specification and assembly requires the targeted deposition of specialized
nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A …

Satellite DNAs represent the most abundant fraction of repetitive sequences in genomes of
almost all eukaryotic species. Long arrays of satellite DNA monomers form densely packed …

Satellite DNAs (tandemly repeated, non-coding DNA sequences) stretch over almost all
native centromeres and surrounding pericentromeric heterochromatin. Once considered as …

Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic
centromeres have been shown to be an astonishing example of epigenetic change within …

The centromere is a chromosomal locus responsible for the faithful segregation of genetic
material during cell division. It has become evident that centromeres can be established …

Background Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-
seq) has recently been used to identify the modification patterns for the methylation and …