Cancer is a life-threatening disease, and there is a significant need for novel technologies to
treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a …

Carbonic anhydrases (CAs; EC 4.2. 1.1) are well known zinc metalloproteins involved in the
catalysis of a very simple but essential physiological reaction: carbon dioxide hydration to …

Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-
dependent cancer treatment. Herein, we have developed all-organic oxygen-independent …

Carbonic anhydrase (CA) IX overexpresses exclusively on cell membranes of hypoxic
tumors, regulating the acidic tumor microenvironment. Small molecules of CA inhibitor …

Solid tumors are complex entities, comprising a wide variety of malignancies with very
different molecular alterations. Despite this, they share a set of characteristics known as …

Hypoxia is a common feature of solid tumors contributing to resistance to chemotherapy.
Selective delivery of chemotherapeutic drugs to hypoxic tumor niche remains an unsolved …

Plasmonic particles as gold nanorods have emerged as powerful contrast agents for critical
applications as the photoacoustic imaging and photothermal ablation of cancer. However …

A series of monothiocarbamates (MTCs) were prepared from primary/secondary amines and
COS as potential carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors, using the …

Four groups of novel sulfonamide derivatives:(i) acetoxybenzamide,(ii)
triacetoxybenzamide,(iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having …

We report for the first time Antibody-Drug-Conjugates (ADCs) containing human (h)
Carbonic Anhydrase (CA; EC 4.2. 1.1) directed Monoclonal Antibodies (MAbs) linked to low …