Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects

B Le Dare, V Lagente, T Gicquel - Drug metabolism reviews, 2019 - Taylor & Francis
This article summarizes recent experimental and epidemiological data on the toxic and
beneficial effects of ethanol and its metabolites (acetaldehyde), and focuses on their …

Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function

H Salmanzadeh, SM Ahmadi-Soleimani… - Brain research …, 2020 - Elsevier
Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Brain disorders? Not really: Why network structures block reductionism in psychopathology research

D Borsboom, AOJ Cramer, A Kalis - Behavioral and Brain Sciences, 2019 - cambridge.org
In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

A Gulbins, F Schumacher, KA Becker, B Wilker… - Molecular …, 2018 - nature.com
Major depressive disorder (MDD) is a common and severe disease characterized by mood
changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the …

Sphingolipid control of cognitive functions in health and disease

LS Kalinichenko, E Gulbins, J Kornhuber… - Progress in lipid …, 2022 - Elsevier
Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Serotonin signaling through lipid membranes

LS Kalinichenko, J Kornhuber, S Sinning… - ACS Chemical …, 2024 - ACS Publications
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …

Self-management with alcohol over lifespan: psychological mechanisms, neurobiological underpinnings, and risk assessment

CP Müller, G Schumann, J Rehm, J Kornhuber… - Molecular …, 2023 - nature.com
Self-management includes all behavioural measures and cognitive activities aimed at
co** with challenges arising throughout the lifespan. While virtually all of these challenges …

[HTML][HTML] Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation …

D van Kruining, Q Luo, G van Echten-Deckert… - Advanced drug delivery …, 2020 - Elsevier
Lipids play an important role in neurodegeneration, neuroinflammation, and psychiatric
disorders and an imbalance in sphingolipid levels is associated with disease. Although early …

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

LS Kalinichenko, C Mühle, T Jia, F Anderheiden… - Molecular …, 2021 - nature.com
Mental disorders are highly comorbid and occur together with physical diseases, which are
often considered to arise from separate pathogenic pathways. We observed in alcohol …

Non-pharmacological factors that determine drug use and addiction

SH Ahmed, A Badiani, KA Miczek, CP Müller - … & Biobehavioral Reviews, 2020 - Elsevier
Based on their pharmacological properties, psychoactive drugs are supposed to take control
of the natural reward system to finally drive compulsory drug seeking and consumption …