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Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects
This article summarizes recent experimental and epidemiological data on the toxic and
beneficial effects of ethanol and its metabolites (acetaldehyde), and focuses on their …
beneficial effects of ethanol and its metabolites (acetaldehyde), and focuses on their …
Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function
Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …
brain development and maturation. The refinement and maturation of the central nervous …
Brain disorders? Not really: Why network structures block reductionism in psychopathology research
In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …
policies in clinical psychology and psychiatry. The intense search for the biological basis of …
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
A Gulbins, F Schumacher, KA Becker, B Wilker… - Molecular …, 2018 - nature.com
Major depressive disorder (MDD) is a common and severe disease characterized by mood
changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the …
changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the …
Sphingolipid control of cognitive functions in health and disease
LS Kalinichenko, E Gulbins, J Kornhuber… - Progress in lipid …, 2022 - Elsevier
Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …
mediating the successful adaptation of individuals to constantly changing environmental …
Serotonin signaling through lipid membranes
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …
Self-management with alcohol over lifespan: psychological mechanisms, neurobiological underpinnings, and risk assessment
Self-management includes all behavioural measures and cognitive activities aimed at
co** with challenges arising throughout the lifespan. While virtually all of these challenges …
co** with challenges arising throughout the lifespan. While virtually all of these challenges …
[HTML][HTML] Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation …
Lipids play an important role in neurodegeneration, neuroinflammation, and psychiatric
disorders and an imbalance in sphingolipid levels is associated with disease. Although early …
disorders and an imbalance in sphingolipid levels is associated with disease. Although early …
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Mental disorders are highly comorbid and occur together with physical diseases, which are
often considered to arise from separate pathogenic pathways. We observed in alcohol …
often considered to arise from separate pathogenic pathways. We observed in alcohol …
Non-pharmacological factors that determine drug use and addiction
Based on their pharmacological properties, psychoactive drugs are supposed to take control
of the natural reward system to finally drive compulsory drug seeking and consumption …
of the natural reward system to finally drive compulsory drug seeking and consumption …