Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …

Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Rationale: Chronic hypoxia induces pulmonary vascular remodeling, pulmonary
hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms …

Vascular remodeling in chronic hypoxic pulmonary hypertension includes marked
fibroproliferative changes in the pulmonary artery (PA) adventitia. Although resident PA …

Background—Lung inflammation precedes the development of hypoxia-induced pulmonary
hypertension (HPH); however, its role in the pathogenesis of HPH is poorly understood. We …

Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular
tone and a complex series of cellular and molecular events termed 'vascular remodelling' …

Vascular remodeling is the process of structural alteration and cell rearrangement of blood
vessels in response to injury and is the cause of many of the world's most afflicted …

Excess smooth muscle accumulation is a key component of many vascular disorders,
including atherosclerosis, restenosis, and pulmonary artery hypertension, but the underlying …

Vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH) involves
hyperproliferative and apoptosis-resistant pulmonary artery endothelial cells. In this study …