Cellular pathophysiology of ischemic acute kidney injury
JV Bonventre, L Yang - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …
we review the major components of this dynamic process, which involves hemodynamic …
ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis
AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications
JL Alge, JM Arthur - Clinical Journal of the American Society of …, 2015 - journals.lww.com
AKI is a common clinical condition associated with a number of adverse outcomes. More
timely diagnosis would allow for earlier intervention and could improve patient outcomes …
timely diagnosis would allow for earlier intervention and could improve patient outcomes …
ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli
SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
Mas and its related G protein–coupled receptors, Mrgprs
M Bader, N Alenina, MA Andrade-Navarro… - Pharmacological …, 2014 - Elsevier
The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …
ACE2, angiotensin-(1–7), and Mas: the other side of the coin
M Bader - Pflügers Archiv-European Journal of Physiology, 2013 - Springer
The renin–angiotensin system (RAS) has recently been extended by the addition of a novel
axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide …
axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide …
Severe acute respiratory syndrome coronavirus 2, COVID-19, and the renin-angiotensin system: pressing needs and best research practices
The coronavirus disease 2019 (COVID-19) pandemic is associated with significant morbidity
and mortality throughout the world, predominantly due to lung and cardiovascular injury. The …
and mortality throughout the world, predominantly due to lung and cardiovascular injury. The …
Renal manifestations of Covid-19: physiology and pathophysiology
Z Armaly, S Kinaneh, K Skorecki - Journal of clinical medicine, 2021 - mdpi.com
Corona virus disease 2019 (COVID-19) imposes a serious public health pandemic affecting
the whole world, as it is spreading exponentially. Besides its high infectivity, SARS-CoV-2 …
the whole world, as it is spreading exponentially. Besides its high infectivity, SARS-CoV-2 …
ACE2 alterations in kidney disease
Abstract Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that
degrades angiotensin (Ang) II to Ang-(1–7). ACE2 is highly expressed within the kidneys, it …
degrades angiotensin (Ang) II to Ang-(1–7). ACE2 is highly expressed within the kidneys, it …