The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …

BackgroundConverging lines of evidence implicate an important role for the immune system
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …

Alzheimer's disease is characterized by the histopathological presence of amyloid-β
plaques and tau-containing neurofibrillary tangles. Microglial activation is also a recognized …

Objective: The purpose of this study was to determine whether microglial activity, measured
using translocator-protein positron emission tomography (PET) imaging, is increased in …

The 18-kDA translocator protein (TSPO) is consistently elevated in activated microglia of the
central nervous system (CNS) in response to a variety of insults as well as …

Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …

A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

The 18 kDa translocator protein (TSPO) is a widely used target for microglial PET imaging
radioligands, but its expression in post‐mortem normal and diseased human brain is not …

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Several lines of evidence suggest aberrant immune response in schizophrenia, including
elevated levels of cytokines. These cytokines are thought to be produced by activated …