Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016 - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives

HS El-Sawy, AM Al-Abd, TA Ahmed, KM El-Say… - ACS …, 2018 - ACS Publications
The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …

Chemotherapy mediated by biomimetic polymeric nanoparticles potentiates enhanced tumor immunotherapy via amplification of endoplasmic reticulum stress and …

Y Guo, Y Fan, Z Wang, G Li, M Zhan, J Gong… - Advanced …, 2022 - Wiley Online Library
Construction of multifunctional nanoplatforms to elevate chemotherapeutic efficacy and
induce long‐term antitumor immunity still remains to be an extreme challenge. Herein, the …

[HTML][HTML] The smart drug delivery system and its clinical potential

D Liu, F Yang, F **ong, N Gu - Theranostics, 2016 - ncbi.nlm.nih.gov
With the unprecedented progresses of biomedical nanotechnology during the past few
decades, conventional drug delivery systems (DDSs) have been involved into smart DDSs …

Diverse applications of nanomedicine

B Pelaz, C Alexiou, RA Alvarez-Puebla, F Alves… - ACS …, 2017 - ACS Publications
The design and use of materials in the nanoscale size range for addressing medical and
health-related issues continues to receive increasing interest. Research in nanomedicine …

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

P Grossen, D Witzigmann, S Sieber… - Journal of Controlled …, 2017 - Elsevier
The lack of efficient therapeutic options for many severe disorders including cancer spurs
demand for improved drug delivery technologies. Nanoscale drug delivery systems based …

Amphiphiles self‐assembly: basic concepts and future perspectives of supramolecular approaches

D Lombardo, MA Kiselev, S Magazù… - … in Condensed Matter …, 2015 - Wiley Online Library
Amphiphiles are synthetic or natural molecules with the ability to self‐assemble into a wide
variety of structures including micelles, vesicles, nanotubes, nanofibers, and lamellae. Self …

Nucleic acid therapeutics using polyplexes: a journey of 50 years (and beyond)

U Lächelt, E Wagner - Chemical reviews, 2015 - ACS Publications
Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Stimuli-responsive polymersomes for biomedical applications

X Hu, Y Zhang, Z **e, X **g, A Bellotti, Z Gu - Biomacromolecules, 2017 - ACS Publications
Polymersomes, the structural analogues of liposomes, are hollow structures enclosed by a
bilayer membrane made from amphiphilic copolymers. Polymersomes have been proposed …

Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance

Z Ge, S Liu - Chemical Society Reviews, 2013 - pubs.rsc.org
Self-assembled nanostructures of amphiphilic and double hydrophilic block copolymers
have been increasingly utilized as potent polymeric nanocarriers of therapeutic drugs …