Serotonin (5-HT)-receptor-based mechanisms have been postulated to play a critical role in
the action of the new generation of antipsychotic drugs (APDs) that are usually referred to as …

The glutamate system is involved in many aspects of neuronal synaptic strength and
function during development and throughout life. Synapse formation in early brain …

Abstract Second-generation antipsychotics (SGAs), such as risperidone, clozapine and
olanzapine, are the most common drug treatments for schizophrenia. SGAs presented an …

Antipsychotic medications are critical to child and adolescent psychiatry, from the
stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic …

The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …

Molecular imaging studies have generated important in vivo insights into the etiology of
schizophrenia and treatment response. This article first reviews the PET and SPECT …

Background: Depression, hopelessness, impaired problem solving capacities and deficient
serotonergic functions have been identified as major causes of suicidal behaviour. In …

The serotonergic system plays a key modulatory role in the brain and is the target for many
drug treatments for brain disorders either through reuptake blockade or via interactions at …

Newer atypical antipsychotic drugs such as risperidone, olanzapine, quetiapine, ziprasidone
and aripiprazole that have been modelled on the prototype agent clozapine and developed …

Based on recent insight into the thalamocortical system and its role in perception and
conscious experience, a unified pathophysiological framework for hallucinations in …