Prebiotic chemistry aims to explain how the biochemistry of life as we know it came to be.
Most efforts in this area have focused on provisioning compounds of importance to life by …

Aminotransferases (ATs) are pyridoxal 5′-phosphate–dependent enzymes that catalyze
the transamination reactions between amino acid donor and keto acid acceptor substrates …

For the investigation of chemical reaction networks, the identification of all relevant
intermediates and elementary reactions is mandatory. Many algorithmic approaches exist …

The reverse tricarboxylic acid (rTCA) cycle (also known as the reverse Krebs cycle) is a
central anabolic biochemical pathway whose origins are proposed to trace back to …

Efforts to decipher the prebiotic roots of metabolic pathways have focused on recapitulating
modern biological transformations, with metals typically serving in place of cofactors and …

The importance of autocatalysis spans from practical applications such as in chemically
amplified photoresists, to autocatalysis playing a fundamental role in evolution as well as a …

Life is that which replicates and evolves, but there is no consensus on how life emerged. We
advocate a systems protobiology view, whereby the first replicators were assemblies of …

For the investigation of chemical reaction networks, the efficient and accurate determination
of all relevant intermediates and elementary reactions is mandatory. The complexity of such …

To date, the program for the development of methods and models for atomistic and
continuum simulation directed toward chemicals and materials has reached an incredible …

The construction of a reaction network containing all relevant intermediates and elementary
reactions is necessary for the accurate description of chemical processes. In the case of a …