Simulation studies of amyloidogenic polypeptides and their aggregates
Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …
Protein–surfactant interactions: a tale of many states
D Otzen - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2011 - Elsevier
The scientific study of protein surfactant interactions goes back more than a century, and has
been put to practical uses in everything from the estimation of protein molecular weights to …
been put to practical uses in everything from the estimation of protein molecular weights to …
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
The formation of amyloid fibrils by the intrinsically disordered protein α-synuclein is a
hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of …
hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of …
[HTML][HTML] Biosurfactants and surfactants interacting with membranes and proteins: same but different?
DE Otzen - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2017 - Elsevier
Biosurfactants (BS) are surface-active molecules produced by microorganisms. For several
decades they have attracted interest as promising alternatives to current petroleum-based …
decades they have attracted interest as promising alternatives to current petroleum-based …
[HTML][HTML] How do surfactants unfold and refold proteins?
Although the anionic surfactant sodium dodecyl sulfate, SDS, has been used for more than
half a century as a versatile and efficient protein denaturant for protein separation and size …
half a century as a versatile and efficient protein denaturant for protein separation and size …
Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation
C Cabaleiro-Lago, F Quinlan-Pluck… - ACS chemical …, 2010 - ACS Publications
The fibrillation kinetics of the amyloid β peptide is analyzed in presence of cationic
polystyrene nanoparticles of different size. The results highlight the importance of the ratio …
polystyrene nanoparticles of different size. The results highlight the importance of the ratio …
Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation
Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …
aggregates under various conditions inside the cell. Such transitions confer diverse …
Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation
L Giehm, DI Svergun, DE Otzen… - Proceedings of the …, 2011 - pnas.org
One of the major hallmarks of Parkinson disease is aggregation of the protein α-synuclein
(αSN). Aggregate cytotoxicity has been linked to an oligomeric species formed at early …
(αSN). Aggregate cytotoxicity has been linked to an oligomeric species formed at early …
Applications of isothermal titration calorimetry in pure and applied research—survey of the literature from 2010
Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …
and dissociation of molecular complexes and has become an invaluable tool in many …
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system
Controlling molecular interactions between bioinspired molecules can enable the
development of new materials with higher complexity and innovative properties. Here we …
development of new materials with higher complexity and innovative properties. Here we …