The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and
a major risk factor for morbidity and mortality. The abundant cell-free nucleic (DNA/RNA) in …

Plasmacytoid dendritic cells (pDCs) produce large amounts of type I interferons (IFN-α/β) in
response to viral or endogenous nucleic acids through activation of their endosomal Toll-like …

Abstract Type I interferons (IFN-Is) are a group of molecules with pleiotropic effects on the
immune system forming a crucial link between innate and adaptive immune responses …

Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …

Autoreactive B and T cells are present in healthy, autoimmunity-free individuals, but they are
kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) …

MicroRNAs (miRNAs) have been implicated in B cell lineage commitment, regulation of T
cell differentiation, TCR signalling, regulation of IFN signalling, and numerous other …

Many patients with systemic autoimmune diseases have signs of a continuous production of
type I interferon (IFN) and display an increased expression of IFN-α-regulated genes. The …

The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting
disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their …

Systemic lupus erythematosus (SLE) is a complex auto‐immune disorder which involves
various facets of the immune system. In addition to autoantibody production and immune …