Bioprocessing in the digital age: the role of process models

H Narayanan, MF Luna, M von Stosch… - Biotechnology …, 2020 - Wiley Online Library
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

Digital Twin in biomanufacturing: Challenges and opportunities towards its implementation

IA Udugama, PC Lopez, CL Gargalo, X Li… - Systems Microbiology …, 2021 - Springer
The domain of industrial biomanufacturing is enthusiastically embracing the concept of
Digital Twin, owing to its promises of increased process efficiency and resource utilisation …

Applied and computational optimal control

KL Teo, B Li, C Yu, V Rehbock - Optimization and Its Applications, 2021 - Springer
For an optimal control problem, one seeks to optimize a performance measure subject to a
set of dynamic, and possibly algebraic, constraints. The dynamic constraints may be …

Advances in bioconversion of glycerol to 1, 3-propanediol: prospects and challenges

YQ Sun, JT Shen, L Yan, JJ Zhou, LL Jiang, Y Chen… - Process …, 2018 - Elsevier
Propanediol, a monomer for synthesis of polytrimethylene terephthalate, polyethers,
polyurethanes, and heterocyclic compounds, has attracted worldwide attention. It can be …

Multi‐rate observer design and optimal control to maximize productivity of an industry‐scale fermentation process

P Shah, MZ Sheriff, MSF Bangi, C Kravaris… - AIChE …, 2023 - Wiley Online Library
Chemical industries focus primarily on profitable operations, resulting in growing attention
and advances in the field of digital twins and optimal control algorithms. However, most …

Towards the development of digital twins for the bio-manufacturing industry

CL Gargalo, SC de Las Heras, MN Jones… - Digital twins: Tools and …, 2021 - Springer
The bio-manufacturing industry, along with other process industries, now has the opportunity
to be engaged in the latest industrial revolution, also known as Industry 4.0. To successfully …

In Vivo Real-Time Control of Gene Expression: A Comparative Analysis of Feedback Control Strategies in Yeast

G Fiore, G Perrino, M Di Bernardo… - ACS synthetic …, 2016 - ACS Publications
Real-time automatic regulation of gene expression is a key technology for synthetic biology
enabling, for example, synthetic circuit's components to operate in an optimal range …

Fermentation process control and optimization

WY Chai, KTK Teo, MK Tan… - Chemical Engineering & …, 2022 - Wiley Online Library
Process control and optimization is important in ensuring a process in sustaining profitable
income while maintaining the required quality. The fermentation process has attracted …

Fed-batch ethanol fermentation at low temperature as a way to obtain highly concentrated alcoholic wines: Modeling and optimization

IIK Veloso, KCS Rodrigues, JLS Sonego… - Biochemical …, 2019 - Elsevier
The effect of product inhibition on yeast hinders the production of wine with ethanol
concentration above 80.0 g L− 1 (∼ 10° GL) in the industrial ethanol production process …

[HTML][HTML] Phosphate Solubilizing Microorganism Bacillus sp. MVY-004 and Its Significance for Biomineral Fertilizers' Development in Agrobiotechnology

R Mažylytė, J Kaziūnienė, L Orola, V Valkovska… - Biology, 2022 - mdpi.com
Simple Summary Agriculture is one of the most significant and important sectors globally.
Soil fertility and agricultural production are highly dependent on which plant protection and …