Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system
(CNS). A body of research over recent years has demonstrated a key role for mitogen …

BRAF represents one of the most frequently mutated protein kinase genes in human
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …

Activation of the MAPK signaling pathway has been shown to be a unifying molecular
feature in pilocytic astrocytoma (PA). Genetically, tandem duplications at chromosome 7q34 …

For some, glioma biomarkers have been expected to solve common diagnostic problems in
routine neuropathology service caused by insufficient material, technical shortcomings or …

Recent studies highlight the importance of BRAF alterations resulting in mitogen activated
protein kinase (MAK/ERK) pathway activation in low-grade CNS tumors. We studied 106 low …

Abstract BRAF rearrangements and BRAF V600E point mutations are recurring events in
pediatric low-grade gliomas. However, their clinical significance, including possible …

The advances of genome‐wide 'discovery platforms' and the increasing affordability of the
analysis of significant sample sizes have led to the identification of novel mutations in brain …

Alterations in BRAF have been discovered in most pediatric low-grade gliomas. Because the
field has moved quickly during the past few years, there is not yet widespread awareness …

The mitogen-activated protein kinase (MAPK) pathway is known to play a key role in the
initiation and maintenance of many tumors as well as normal development. This often occurs …

Context.—Gliomas are the most common primary brain tumors of adults and include a
variety of histologic types and morphologies. Histologic evaluation remains the gold …