Causal variants for rare genetic diseases are often rare in the general population. Rare
variants may also contribute to common complex traits and can have much larger per-allele …

Childhood adversity (CA) as a significant stressor has consistently been associated with the
development of mental disorders. The interaction between CA and genetic variants has …

With increasing biobanking efforts connecting electronic health records and national
registries to germline genetics, the time-to-event data analysis has attracted increasing …

Importance Uncertainty currently exists about whether the same genetic variants are
associated with susceptibility to low myopia (LM) and high myopia (HM) and to myopia and …

In genome-wide association studies, ordinal categorical phenotypes are widely used to
measure human behaviors, satisfaction, and preferences. However, because of the lack of …

In biobank data analysis, most binary phenotypes have unbalanced case-control ratios, and
this can cause inflation of type I error rates. Recently, a saddle point approximation (SPA) …

Motivation Gene–environment interaction (GEI) studies are a general framework that can be
used to identify genetic variants that modify the effects of environmental, physiological …

Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …

Most human complex phenotypes result from multiple genetic and environmental factors and
their interactions. Understanding the mechanisms by which genetic and environmental …

Complex human diseases are affected by genetic and environmental risk factors and their
interactions. Gene–environment interaction (GEI) tests for aggregate genetic variant sets …