Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at
the cell cortex or in association with other cytoskeletal proteins, such as actin or …

One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …

Most human cells require anchorage for survival. Cell–substrate adhesion activates diverse
signalling pathways, without which cells undergo anoikis—a form of programmed cell death …

The cytoskeleton of a cell controls all the aspects of cell shape changes and motility from its
physiological functions for survival to reproduction to death. The structure and dynamics of …

Septins are conserved cytoskeletal proteins that regulate cell cortex mechanics. The
mechanisms of their interactions with the plasma membrane remain poorly understood …

The ability of cells to sense and communicate their shape is central to many of their
functions. Much is known about how cells generate complex shapes, yet how they sense …

Septins are involved in many important cellular processes, and septin dysfunction has been
implicated in various pathologies, such as cancer. Like other components of the …

In order to form functional filaments, human septins must assemble into hetero-oligomeric
rod-like particles which polymerize end-to-end. The rules governing the assembly of these …

Septins are conserved GTP-binding cytoskeletal proteins that polymerize into filaments by
end-to-end joining of hetero-oligomeric complexes. In human cells, both hexamers and …

In metazoans, living cells achieve capabilities beyond individual cell functionality by
assembling into multicellular tissue structures. These higher-order structures represent …