Bile acid–gut microbiota axis in inflammatory bowel disease: from bench to bedside
M Yang, Y Gu, L Li, T Liu, X Song, Y Sun, X Cao… - Nutrients, 2021 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the
gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear …
gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear …
Animal models of ulcerative colitis and their application in drug research
D Low, DD Nguyen, E Mizoguchi - Drug design, development and …, 2013 - Taylor & Francis
The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even
more difficult to decipher the pathophysiology to explain for the similarities and differences …
more difficult to decipher the pathophysiology to explain for the similarities and differences …
[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation
While it has long been known that inflammation and infection reduce expression of hepatic
cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to …
cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to …
Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells
G Englund, F Rorsman, A Rönnblom, U Karlbom… - European journal of …, 2006 - Elsevier
A vast number of drugs are subjected to active or facilitated transport and multiple transport
mechanism may contribute to the net flux during drug absorption. The main objective of this …
mechanism may contribute to the net flux during drug absorption. The main objective of this …
[HTML][HTML] Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice
J Xu, X Wang, J Chen, S Chen, Z Li, H Liu, Y Bai… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Rationale: Mesenchymal stem cells (MSCs) show promising therapeutic potential in
treating inflammatory bowel disease (IBD) due to their immunomodulatory and trophic …
treating inflammatory bowel disease (IBD) due to their immunomodulatory and trophic …
Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects
Nuclear receptors (NRs) are ligand-activated transcription factors sharing a common
evolutionary history and having similar sequence features at the protein level. Selective …
evolutionary history and having similar sequence features at the protein level. Selective …
Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues
P Pavek, Z Dvorak - Current drug metabolism, 2008 - ingentaconnect.com
Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …
The gut microbiota at the intersection of bile acids and intestinal carcinogenesis: an old story, yet mesmerizing
T Liu, X Song, S Khan, Y Li, Z Guo, C Li… - … journal of cancer, 2020 - Wiley Online Library
The prevalence of colorectal cancer (CRC) has markedly increased worldwide in the last
decade. Alterations of bile acid metabolism and gut microbiota have been reported to play …
decade. Alterations of bile acid metabolism and gut microbiota have been reported to play …