Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

Quantitative empirical relationships between cell composition and growth rate played an
important role in the early days of microbiology. Gradually, the focus of the field began to …

In bacteria, the rate of cell proliferation and the level of gene expression are intimately
intertwined. Elucidating these relations is important both for understanding the physiological …

We are interested in the balance of energy and protein synthesis in bacterial growth. How
has evolution optimized this balance? We describe an analytical model that leverages …

In natural settings, microbes tend to grow in dense populations,,, where they need to push
against their surroundings to accommodate space for new cells. The associated contact …

In the unicellular eukaryote Saccharomyces cerevisiae, Cln3–cyclin-dependent kinase
activity enables Start, the irreversible commitment to the cell division cycle. However, the …

Most cells live in environments that are permissive for proliferation only a small fraction of
the time. Entering quiescence enables cells to survive long periods of nondivision and …

Carbon catabolite repression (CCR) controls the order in which different carbon sources are
metabolized. Although this system is one of the paradigms of the regulation of gene …

Besides being the favorite carbon and energy source for the budding yeast Sacchromyces
cerevisiae, glucose can act as a signaling molecule to regulate multiple aspects of yeast …

Is a group best off if everyone co-operates? Theory often considers this to be so (eg the
“conspiracy of doves”), this understanding underpinning social and economic policy. We …