Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

The extracellular matrix (ECM) composition greatly influences cancer progression, leading
to differential invasion, migration, and metastatic potential. In breast cancer, ECM …

Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …

Microphysiological and organ‐on‐chip platforms seek to address critical gaps in human
disease models and drug development that underlie poor rates of clinical success for novel …

As the conversion rate of preclinical studies for cancer treatment is low, user-friendly models
that mimic the pathological microenvironment and drug intake with high throughput are …

The knowledge of the blood microvasculature and its functional role in health and disease
has grown significantly attributable to decades of research and numerous advances in cell …

Adequate vascularization is required for the successful translation of many in vitro
engineered tissues. This study presents a novel collagen derivative that harbors multiple …

Traditional drug therapy faces challenges such as drug distribution throughout the body,
rapid degradation and excretion, and extensive adverse reactions. In contrast …