Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours
MT Makale, CR McDonald… - Nature Reviews …, 2017 - nature.com
Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …
Radiation-induced brain injury: a review
D Greene-Schloesser, ME Robbins, AM Peiffer… - Frontiers in …, 2012 - frontiersin.org
Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …
Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: phase III trial NRG oncology CC001
PURPOSE Radiation dose to the neuroregenerative zone of the hippocampus has been
found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity …
found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity …
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced
with increased dose rate. Spatial memory is preserved after WBI with mean dose rates …
with increased dose rate. Spatial memory is preserved after WBI with mean dose rates …
Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation
Aim To evaluate the impact of ultra-rapid FLASH mouse whole brain irradiation on
hippocampal dendritic spines and neuroinflammation, factors associated with cognitive …
hippocampal dendritic spines and neuroinflammation, factors associated with cognitive …
[PDF][PDF] Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation
Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …
[HTML][HTML] Microglia and ischemic stroke: a double-edged sword
Inflammatory processes have a fundamental role in the pathophysiology of stroke. A key
initial event is the rapid activation of resident immune cells, primarily microglia. This cell …
initial event is the rapid activation of resident immune cells, primarily microglia. This cell …
Elimination of microglia improves cognitive function following cranial irradiation
Cranial irradiation for the treatment of brain cancer elicits progressive and severe cognitive
dysfunction that is associated with significant neuropathology. Radiation injury in the CNS …
dysfunction that is associated with significant neuropathology. Radiation injury in the CNS …
[LIVRE][B] Hayes' principles and methods of toxicology
AW Hayes, T Kobets - 2023 - taylorfrancis.com
Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …
informative reference for the concepts, methodologies, and assessments integral to …
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
K Fabel, K Fabel, B Tam, D Kaufer… - European Journal of …, 2003 - Wiley Online Library
Declining learning and memory function is associated with the attenuation of adult
hippocampal neurogenesis. As in humans, chronic stress or depression in animals is …
hippocampal neurogenesis. As in humans, chronic stress or depression in animals is …