Beyond the marks: reader-effectors as drivers of epigenetics and chromatin engineering
Chromatin is a system of proteins and DNA that regulates chromosome organization and
gene expression in eukaryotes. Essential features that support these processes include …
gene expression in eukaryotes. Essential features that support these processes include …
Manipulating cation− π interactions of reader proteins in living cells with genetic code expansion
H Zhao, L Tang, Y Fang, C Liu, W Ding… - Journal of the …, 2023 - ACS Publications
Despite tremendous success in understanding the chemical nature and the importance of
cation− π interactions in a range of biological processes, particularly in epigenetic …
cation− π interactions in a range of biological processes, particularly in epigenetic …
Interactions with histone H3 & tools to study them
WA Scott, EI Campos - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Histones are an integral part of chromatin and thereby influence its structure, dynamics, and
functions. The effects of histone variants, posttranslational modifications, and binding …
functions. The effects of histone variants, posttranslational modifications, and binding …
Single-electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins
F Feng, Y Gao, Q Zhao, T Luo, Q Yang, N Zhao… - Nature Chemistry, 2024 - nature.com
The identification of readers, an important class of proteins that recognize modified residues
at specific sites, is essential to uncover the biological roles of post-translational …
at specific sites, is essential to uncover the biological roles of post-translational …
High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression
Histone methylation is an important post-translational modification that plays a crucial role in
regulating cellular functions, and its dysregulation is implicated in cancer and …
regulating cellular functions, and its dysregulation is implicated in cancer and …
Contribution of Electrostatic CH3–π Interactions to Recognition of Histone Asymmetric Dimethylarginine by the SPIN1 Triple Tudor Domain
Methylation of arginine (Arg) residues on histones creates a new binding epitope, enabling
recognition by aromatic cage binding pockets in Tudor domains; these protein–protein …
recognition by aromatic cage binding pockets in Tudor domains; these protein–protein …
Scalable synthesis of sulfonium and selenonium peptides for selective methyllysine reader crosslinking
Y Gao, F Feng, M Wu - Tetrahedron Letters, 2024 - Elsevier
Lysine methylation readers are an important class of proteins that bind site-specifically
methylated proteins for downstream regulation. Chemical probes that crosslink lysine …
methylated proteins for downstream regulation. Chemical probes that crosslink lysine …
Advances and opportunities in epigenetic chemical biology
The study of epigenetics has greatly benefited from the development and application of
various chemical biology approaches. In this review, we highlight the key targets for …
various chemical biology approaches. In this review, we highlight the key targets for …
Selective Triazenation Reaction (STaR) of secondary amines for tagging monomethyl lysine post‐translational modifications
Lysine monomethylation (Kme) is an impactful post‐translational modification (PTM)
responsible for regulating biological processes and implicated in diseases, thus there is …
responsible for regulating biological processes and implicated in diseases, thus there is …
[HTML][HTML] Synthetic Interventions in Epigenome: Unraveling Chromatin's Potential for Therapeutic Applications
J Kim, J Kim, M Park - Current Opinion in Systems Biology, 2024 - Elsevier
The epigenome, comprising DNA and histone modifications alongside intricate chromatin
structures, has emerged as pivotal players in disease development. These factors offer …
structures, has emerged as pivotal players in disease development. These factors offer …