Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Despite being one of the first eukaryotic transcriptional regulatory elements identified, the
sequence of a native TATA box and its significance remain elusive. Applying criteria …

The 2.5 Å crystal structure of a TATA-box complex with yeast TBP shows that the eight base
pairs of the TATA box bind to the concave surface of TBP by bending towards the major …

The three-dimensional structure of a TATA-box binding polypeptide complexed with the
TATA element of the adenovirus major late promoter has been determined by X-ray …

The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …

Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-
acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core …

BINDING of the TATA-binding protein (TBP) to the TATA box is required for transcription from
many eukaryotic promoters in gene expression. Regulation of this binding is therefore likely …

Cocrystal structures of wild-type TATA box-binding protein (TBP) recognizing 10 naturally
occurring TATA elements have been determined at 2.3–1.8 Å resolution, and compared with …