▪ Abstract At the interface between the innate and adaptive immune systems lies the high-
output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine …

Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …

Nitric oxide (NO) has been invoked as an important pathogenic factor in a wide range of
immunologically mediated diseases. The present study demonstrates that macrophage …

Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of
these cell types are capable of producing nitric oxide (NO), either constitutively or in …

A number of pathogenic and proinflammatory stimuli, and the transforming growth factor-β
(TGF-β) exert opposing activities in cellular and immune responses. Here we show that the …

Transforming growth factor β1 (TGF-β1) regulates leukocytes and epithelial cells. To
determine whether the pleiotropic effects of TGF-β1, a cytokine that is produced by both …

The cytokines IL-4 and IL-13 inhibit the production of NO from activated macrophages
through an unresolved molecular mechanism. We show here that IL-4 and IL-13 regulate …

Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral
obstruction. Background Unilateral ureteral obstruction (UUO) is characterized by …

Transforming growth factor‐βs (TGF‐βs) are amongthe most widespread and versatile
cytokines. Here, we first provide a briefoverview of their molecular biology, biochemistry, and …

The soy isoflavone genistein attenuates growth factor–and cytokine-stimulated proliferation
of both normal and cancer cells. This article reviews our current understanding of the …