[HTML][HTML] The chemistry of snake venom and its medicinal potential
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …
Causes and consequences of snake venom variation
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …
species. This variability has serious consequences for the management of the world's 1.8 …
Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
LO Albulescu, C **e, S Ainsworth, J Alsolaiss… - Nature …, 2020 - nature.com
Snakebite is a medical emergency causing high mortality and morbidity in rural tropical
communities that typically experience delayed access to unaffordable therapeutics. Viperid …
communities that typically experience delayed access to unaffordable therapeutics. Viperid …
[HTML][HTML] Beyond the 'big four': Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies
RRS Laxme, S Khochare, HF de Souza… - PLoS neglected …, 2019 - journals.plos.org
Background Snakebite in India causes the highest annual rates of death (46,000) and
disability (140,000) than any other country. Antivenom is the mainstay treatment of …
disability (140,000) than any other country. Antivenom is the mainstay treatment of …
Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism
Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent
observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms. As …
observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms. As …
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
K Suryamohan, SP Krishnankutty, J Guillory, M Jevit… - Nature Genetics, 2020 - nature.com
Snakebite envenoming is a serious and neglected tropical disease that kills~ 100,000
people annually. High-quality, genome-enabled comprehensive characterization of toxin …
people annually. High-quality, genome-enabled comprehensive characterization of toxin …
Convergent evolution of pain-inducing defensive venom components in spitting cobras
Convergent evolution provides insights into the selective drivers underlying evolutionary
change. Snake venoms, with a direct genetic basis and clearly defined functional …
change. Snake venoms, with a direct genetic basis and clearly defined functional …
A current perspective on snake venom composition and constituent protein families
T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …
Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across …
Snake venom variations are a crucial factor to understand the consequences of snakebite
envenoming worldwide, and therefore it is important to know about toxin composition …
envenoming worldwide, and therefore it is important to know about toxin composition …