Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

The shotgun proteomic analysis is currently the most promising single-cell protein
sequencing technology, however its identification level of~ 1000 proteins per cell is still …

The ubiquitin system regulates virtually all aspects of cellular function. We report a method to
target the myriad enzymes that govern ubiquitination of protein substrates. We used …

When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …

Protein ubiquitylation is a widespread post-translational modification, regulating cellular
signalling with many outcomes, such as protein degradation, endocytosis, cell cycle …

The heat-shock response is a complex cellular program that induces major changes in
protein translation, folding and degradation to alleviate toxicity caused by protein misfolding …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

Protein quality control (PQC) machineries play a critical role in selective identification and
removal of mistargeted, misfolded, and aberrant proteins. This task is extremely complicated …

PRMT5 (protein arginine methyltransferase 5) is an enzyme that catalyses transfer of methyl
groups from S-adenosyl methionine to the arginine residues of histones or non-histone …