The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key
physiological processes and thus have long been attractive drug targets. With the crystal …

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for probing structure,
dynamics, folding, and interactions at atomic resolution. While naturally occurring …

G-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment
to intracellular proteins. To gain structural insight into the regulation of receptor cytoplasmic …

Extracellular ligand binding to G protein–coupled receptors (GPCRs) modulates G protein
and β-arrestin signaling by changing the conformational states of the cytoplasmic region of …

Signaling across cellular membranes, the 826 human G protein-coupled receptors (GPCRs)
govern a wide range of vital physiological processes, making GPCRs prominent drug …

Due to the lack of genetically encoded probes for fluorine-19 nuclear magnetic resonance
spectroscopy (19F NMR), its utility for probing eukaryotic membrane protein dynamics is …

This book explores important new NMR spectroscopic methods and describes and
compares the application of NMR to a large variety of useful materials with results from other …

While traditional 1H, 13C, and 15N (HCN) solution state NMR protocols provide a wealth of
data on protein structure and dynamics, 19F NMR provides a unique perspective of …

G protein-coupled receptors (GPCRs) are versatile signaling proteins that mediate complex
cellular responses to hormones and neurotransmitters. Recent advances in GPCR …

In the G protein-coupled receptor rhodopsin, the conserved NPxxY (x) 5, 6F motif connects
the transmembrane helix VII and the cytoplasmic helix 8. The less geometrically constrained …