Room temperature synthesis of bioactive 1, 2, 4-oxadiazoles
1, 2, 4-Oxadiazole is an essential motif in drug discovery represented in many experimental,
investigational, and marketed drugs. This review covers synthetic methods that allow the …
investigational, and marketed drugs. This review covers synthetic methods that allow the …
Anti-inflammatory and Antimicrobial Potential of 1, 3, 4-oxadiazoles and its Derivatives: A Review
T Chaudhary, PK Upadhyay… - Current Organic …, 2024 - ingentaconnect.com
1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial
property. Their precise mechanism of action is not known but it is postulated that they act by …
property. Their precise mechanism of action is not known but it is postulated that they act by …
Identification of potential N-substituted 5-benzylidenethiazolidine-2, 4‑dione derivatives as α-amylase inhibitors: Computational cum synthetic studies
Diabetes mellitus is a chronic metabolic disorder become a major health problem globally
associated with social and economic consequences. α-amylase is an endo-amylase …
associated with social and economic consequences. α-amylase is an endo-amylase …
Dipeptidyl peptidase 4 inhibitors in type 2 diabetes mellitus management: Pharmacophore virtual screening, molecular docking, pharmacokinetic evaluations, and …
D Istrate, L Crisan - Processes, 2023 - mdpi.com
Dipeptidyl Peptidase 4 (DPP-4) expressed on the surface of many different cells is a
promising target to develop new candidates for Type 2 diabetes mellitus (T2DM) …
promising target to develop new candidates for Type 2 diabetes mellitus (T2DM) …
Modes of action of a novel c-myc inhibiting 1, 2, 4-oxadiazole derivative in leukemia and breast cancer cells
The c-MYC oncogene regulates multiple cellular activities and is a potent driver of many
highly aggressive human cancers, such as leukemia and triple-negative breast cancer. The …
highly aggressive human cancers, such as leukemia and triple-negative breast cancer. The …
Synthesis, Cytotoxic, and Computational Screening of Some Novel Indole–1,2,4-Triazole-Based S-Alkylated N-Aryl Acetamides
Molecular hybridization has emerged as the prime and most significant approach for the
development of novel anticancer chemotherapeutic agents for combating cancer. In this …
development of novel anticancer chemotherapeutic agents for combating cancer. In this …
Bis (benzimidazol‐2‐yl) amine‐Based DPP‐4 Inhibitors Potentially Suitable for Combating Diabetes and Associated Nervous System Alterations
K Tomović Pavlović, BS Ilić, L Leitzbach… - Chemistry & …, 2024 - Wiley Online Library
Abstract Bis (benzimidazol‐2‐yl) amine scaffold is not present in dipeptidyl peptidase‐4
(DPP‐4) inhibitors published so far. Herein, the inhibitory potential of bis (benzimidazol‐2 …
(DPP‐4) inhibitors published so far. Herein, the inhibitory potential of bis (benzimidazol‐2 …
Coumarin-based sulfonamide derivatives as potential DPP-IV inhibitors: Pre-ADME analysis, toxicity profile, computational analysis, and in vitro enzyme assay
PK Vawhal, SB Jadhav, S Kaushik, KC Panigrahi… - Molecules, 2023 - mdpi.com
Recent research on dipeptidyl peptidase-IV (DPP-IV) inhibitors has made it feasible to treat
type 2 diabetes mellitus (T2DM) with minimal side effects. Therefore, in the present …
type 2 diabetes mellitus (T2DM) with minimal side effects. Therefore, in the present …
Mn (III)‐Porphyrin Complex as an Efficient and Recyclable Homogeneous Catalyst for Convenient Synthesis of Thioxo‐4,5‐Dihydro‐3H‐thiazolo Pyrimidin‐2‐One …
This study successfully utilized the Mn (III)–porphyrin complex (Mn (PT) Cl) as an efficient
and recyclable catalyst for a one‐pot, three‐component reaction involving aromatic …
and recyclable catalyst for a one‐pot, three‐component reaction involving aromatic …
Thiol-promoted intermolecular cyclization to synthesize 1, 2, 4-oxadiazoles including tioxazafen under transition metal-free conditions
C Yan, M Zhang, J Li, J Zhang, Y Wu - Organic & Biomolecular …, 2023 - pubs.rsc.org
A simple and efficient one-pot intermolecular annulation reaction for the synthesis of 1, 2, 4-
oxadiazoles from amidoximes and benzyl thiols has been developed, in which benzyl thiols …
oxadiazoles from amidoximes and benzyl thiols has been developed, in which benzyl thiols …