There has been remarkable insight into the importance of platelets in a wide range of
pathophysiologic events, including inflammation and cancer progression. Thrombocytosis in …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

Emerging evidence suggests that bone marrow–derived endothelial, hematopoietic stem
and progenitor cells contribute to tissue vascularization during both embryonic and postnatal …

Platelets, in addition to their function in hemostasis, play an important role in wound healing
and tumor growth. Because platelets contain angiogenesis stimulators and inhibitors, the …

Elevated platelet counts in patients diagnosed with malignant tumors were first described
more than 100 years ago. Today it is well known that in many types of solid tumors …

Formation of lymphatic metastasis is the initial step of generalized spreading of tumor cells
and predicts poor clinical prognosis. Lymphatic vessels generally arise within the …

Blood platelets are here presented as active players in antimicrobial host defense and the
induction of inflammation and tissue repair in addition to their participation in hemostasis …

Melanoma is a lethal melanocytic neoplasm. Unfortunately, the histological diagnosis can
be difficult at times. Distinguishing ambiguous melanocytic neoplasms that are benign nevi …

Although platelets are best known as primary mediators of hemostasis, this function
intimately associates them with inflammatory processes, and it has been increasingly …

Background: Alveolar bone regeneration is frequently necessary prior to placement of
implants. Efforts to improve wound healing have focused on factors that may enhance bone …