Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

New advances in tissue metabolomics: a review

M Saoi, P Britz-McKibbin - Metabolites, 2021 - mdpi.com
Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical
medicine while also providing better understanding of the underlying mechanisms of chronic …

Desorption electrospray ionization mass spectrometry imaging in discovery and development of novel therapies

T Soudah, A Zoabi, K Margulis - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …

Metabolic markers and statistical prediction of serous ovarian cancer aggressiveness by ambient ionization mass spectrometry imaging

M Sans, K Gharpure, R Tibshirani, J Zhang, L Liang… - Cancer research, 2017 - AACR
Ovarian high-grade serous carcinoma (HGSC) results in the highest mortality among
gynecological cancers, develo** rapidly and aggressively. Dissimilarly, serous borderline …

Review and perspectives on the applications of mass spectrometry imaging under ambient conditions

CJ Perez, AK Bagga, SS Prova… - Rapid …, 2019 - Wiley Online Library
Ambient mass spectrometry (AMS)‐based techniques are performed under ambient
conditions in which the ionization and desorption occur in the open environment allowing …

Aggregated molecular phenotype scores: enhancing assessment and visualization of mass spectrometry imaging data for tissue-based diagnostics

JR Chappel, ME King, J Fleming, LS Eberlin… - Analytical …, 2023 - ACS Publications
Mass spectrometry imaging (MSI) has gained increasing popularity for tissue-based
diagnostics due to its ability to identify and visualize molecular characteristics unique to …

A review on recent machine learning applications for imaging mass spectrometry studies

A Jetybayeva, N Borodinov, AV Ievlev… - Journal of Applied …, 2023 - pubs.aip.org
Imaging mass spectrometry (IMS) is a powerful analytical technique widely used in biology,
chemistry, and materials science fields that continue to expand. IMS provides a qualitative …

Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging

ML Dória, JS McKenzie, A Mroz, DL Phelps, A Speller… - Scientific reports, 2016 - nature.com
Ovarian cancer is highly prevalent among European women, and is the leading cause of
gynaecological cancer death. Current histopathological diagnoses of tumour severity are …

Systems immunology approaches to metabolism

DA Mogilenko, A Sergushichev… - Annual Review of …, 2023 - annualreviews.org
Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of
research and yielded significant fundamental insights into the regulation of immune …

Recent advances of ambient ionization mass spectrometry imaging in clinical research

N Li, H Nie, L Jiang, G Ruan, F Du… - Journal of separation …, 2020 - Wiley Online Library
The structural information and spatial distribution of molecules in biological tissues are
closely related to the potential molecular mechanisms of disease origin, transfer, and …