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The pathogenesis of rheumatoid arthritis
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
[HTML][HTML] The etiology of rheumatoid arthritis
Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining
genetic risk factors and autoantibodies, sub-classified into ACPA-positive and-negative RA …
genetic risk factors and autoantibodies, sub-classified into ACPA-positive and-negative RA …
Deciphering the different phases of preclinical inflammatory bowel disease
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …
[HTML][HTML] An overview of autoantibodies in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …
joints. RA is characterized by immune cell infiltration in the joint. The presence of …
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial
Background Individuals with serum antibodies to citrullinated protein antigens (ACPA),
rheumatoid factor, and symptoms, such as inflammatory joint pain, are at high risk of …
rheumatoid factor, and symptoms, such as inflammatory joint pain, are at high risk of …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift
Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …
Preclinical autoimmune disease: a comparison of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and type 1 diabetes
G Frazzei, RF van Vollenhoven, BA de Jong… - Frontiers in …, 2022 - frontiersin.org
The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …
phase of varying length followed by nonspecific signs and symptoms. A variety of …
Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …