Organ-on-a-chip: Recent breakthroughs and future prospects
Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
[HTML][HTML] Stem cells: past, present, and future
W Zakrzewski, M Dobrzyński, M Szymonowicz… - Stem cell research & …, 2019 - Springer
In recent years, stem cell therapy has become a very promising and advanced scientific
research topic. The development of treatment methods has evoked great expectations. This …
research topic. The development of treatment methods has evoked great expectations. This …
3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model
Y Liu, L Peng, L Li, C Huang, K Shi, X Meng, P Wang… - Biomaterials, 2021 - Elsevier
Osteochondral defect repair in osteoarthritis (OA) remains an unsolved clinical problem due
to the lack of enough seed cells in the defect and chronic inflammation in the joint. To …
to the lack of enough seed cells in the defect and chronic inflammation in the joint. To …
3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare
In the last few years, 3D printing has emerged as a promising alternative for the fabrication
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
Surface roughness and substrate stiffness synergize to drive cellular mechanoresponse
Material surface topographic features have been shown to be crucial for tissue regeneration
and surface treatment of implanted devices. Many biomaterials were investigated with …
and surface treatment of implanted devices. Many biomaterials were investigated with …
Physical cues of biomaterials guide stem cell differentiation fate
Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis
Y Dong, Q Zheng, Z Wang, X Lin, Y You, S Wu… - Journal of hematology & …, 2019 - Springer
Background Increased liver stiffness exerts a detrimental role in driving hepatocellular
carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable …
carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable …
Combinatorial wound healing therapy using adhesive nanofibrous membrane equipped with wearable LED patches for photobiomodulation
Wound healing is the dynamic tissue regeneration process replacing devitalized and
missing tissue layers. With the development of photomedicine techniques in wound healing …
missing tissue layers. With the development of photomedicine techniques in wound healing …