Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Despite tremendous progress in the past decade, the complex and heterogeneous nature of
cancer complicates efforts to identify new therapies and therapeutic combinations that …

Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

In recent years, a significant breakthrough has emerged in biology, the identification of
lactylation, a novel post‐translational process. This intriguing modification is not limited to a …

Post-translational modifications of proteins play a pivotal role in both the initiation and
progression of ovarian cancer. Despite the recognition of USP33 as a significant factor in …

DNA methylation, a reversible post-replication modification, defines gene expression and
function in different physiologic processes. Hypomethylation is quite common among global …

Infectious diseases, driven by a diverse array of pathogens, can swiftly undermine public
health systems. Accurate diagnosis and treatment of infectious diseases—centered around …

Lysine acetylation, an evolutionarily conserved post‐translational protein modification, is
reversibly catalyzed by lysine acetyltransferases and lysine deacetylases. Lysine …