Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application

D Lombardo, MA Kiselev - Pharmaceutics, 2022 - mdpi.com
Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by
one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical …

Synthetic biology: bottom-up assembly of molecular systems

S Hirschi, TR Ward, WP Meier, DJ Müller… - Chemical …, 2022 - ACS Publications
The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …

Liposomes or extracellular vesicles: a comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery

A Al-Jipouri, SH Almurisi, K Al-Japairai, LM Bakar… - Polymers, 2023 - mdpi.com
The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention
compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and …

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

K Devantier, VMS Kjær, S Griffin… - British Journal of …, 2024 - Wiley Online Library
Viroporins possess important potential as antiviral targets due to their critical roles during
virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine …

Nanodisc reconstitution and characterization of amyloid-β precursor protein C99

B Krishnarjuna, G Sharma, VM Hiiuk… - Analytical …, 2024 - ACS Publications
Amyloid precursor protein (APP) plays a pivotal role in the pathology of Alzheimer's disease
(AD). Since the fragmentation of the membrane-bound APP that results in the production of …

Insights into the oligomeric structure of the HIV-1 Vpu protein

S Majeed, O Adetuyi, PP Borbat, MM Islam… - Journal of structural …, 2023 - Elsevier
The HIV-1-encoded protein Vpu forms an oligomeric ion channel/pore in membranes and
interacts with host proteins to support the virus lifecycle. However, Vpu molecular …

Membrane protein binding interactions studied in live cells via diethylpyrocarbonate covalent labeling mass spectrometry

ZJ Kirsch, JM Blake, U Huynh, DK Agrohia… - Analytical …, 2023 - ACS Publications
Membrane proteins are vital in the human proteome for their cellular functions and make up
a majority of drug targets in the US However, characterizing their higher-order structures and …

Diethylpyrocarbonate-based covalent labeling mass spectrometry of protein interactions in a membrane complex system

X Pan, T Tran, ZJ Kirsch, LK Thompson… - Journal of the …, 2022 - ACS Publications
Membrane-associated proteins are important because they mediate interactions between a
cell's external and internal environment and they are often targets of therapeutics …

Lipid mimetics: A versatile toolbox for lipid biology and beyond

T Wegner, R Laskar, F Glorius - Current opinion in chemical biology, 2022 - Elsevier
Being the principal component of biological membranes lipids are essential building blocks
of life. Given their huge biological importance, the investigation of lipids, their properties …

[HTML][HTML] Synthetic cell as a platform for understanding membrane-membrane interactions

B Sharma, H Moghimianavval, SW Hwang, AP Liu - Membranes, 2021 - mdpi.com
In the pursuit of understanding life, model membranes made of phospholipids were
envisaged decades ago as a platform for the bottom-up study of biological processes …