Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Abstract A20, encoded by TNFAIP3, is a critical negative regulator of immune activation. A20
is a ubiquitin editing enzyme with multiple domains, each of which mediates or stabilizes a …

Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is characterized by
clonal expansion of natural killer (NK) cells where the underlying genetic mechanisms are …

Large granular lymphocyte (LGL) leukemia comprises a group of rare lymphoproliferative
disorders whose molecular landscape is incompletely defined. We leveraged paired whole …

Clonal expansion of antigen‐specific lymphocytes is the fundamental mechanism enabling
potent adaptive immune responses and the generation of immune memory. Accompanied …

Abstract Large Granular Lymphocyte (LGL) Leukemia is a rare, heterogeneous even more
that once thought, chronic lymphoproliferative disorder characterized by the clonal …

Extranodal NK/T-cell lymphoma is a neoplasm of NK cells or cytotoxic T cells presenting in
extranodal sites, most often in the nasal cavity. The typical immunophenotypes are cCD3+ …

A significant variation in chromatin accessibility is an epigenetic feature of leukemia. The
cause of this variation in leukemia, however, remains elusive. Here, we identify SMARCA5 …