Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Gastric cancer is the fifth most common cancer and the third most common cause of cancer
death globally. Risk factors for the condition include Helicobacter pylori infection, age, high …

Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …

Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of
cancer death. A complex disease arising from the interaction of environmental and host …

Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric
cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial …

Gastric adenocarcinoma (GC) is the third leading cause of global cancer mortality, and the
leading infection-associated cancer with more than 1 million incident cases annually and …

Gastric cancer is a prevalent yet heterogeneous disease. From diet and lifestyle to genetics
and ethnicity, our appreciation of the complexity of gastric cancer has evolved. This review …

Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently
diagnosed malignancy and the third leading cause of cancer related death. Gastric …

Gastric cancer imposes a considerable health burden around the globe despite its declining
incidence. The disease is often diagnosed in advanced stages and is associated with a poor …

Introduction Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated
with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC). E-Cadherin …