Proteins control many vital functions in living cells, such as cell growth and cell division.
Reliable coordination of these functions requires the spatial and temporal organization of …

In order to ascertain their external environment, cells and tissues have the capability to
sense and process a variety of stresses, including stretching and compression forces. These …

A key event at the onset of development is the activation of a contractile actomyosin cortex
during the oocyte-to-embryo transition,–. Here we report on the discovery that, in …

Cell polarity networks are defined by quantitative features of their constituent feedback
circuits, which must be tuned to enable robust and stable polarization, while also ensuring …

Reaction–diffusion networks underlie pattern formation in a range of biological contexts,
from morphogenesis of organisms to the polarization of individual cells. One requirement for …

Proteins become asymmetrically distributed in the one-cell Caenorhabditis elegans embryo
thanks to reaction–diffusion mechanisms that are often entangled in complex feedback …

In the early Caenorhabditis elegans embryo, cell polarization and cytokinesis are
interrelated yet distinct processes. Here, we sought to understand a poorly understood …

The generation of distinct cell fates during development depends on asymmetric cell division
of progenitor cells. In the central and peripheral nervous system of Drosophila, progenitor …

Symmetry breaking is an essential step in cell differentiation and early embryonic
development. However, the molecular cues that trigger symmetry breaking remain largely …

Proper establishment of cell polarity is essential for development. In the one-cell C. elegans
embryo, a centrosome-localised signal provides spatial information for polarity …