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The pathogenesis of Parkinson's disease
HR Morris, MG Spillantini, CM Sue, CH Williams-Gray - The Lancet, 2024 - thelancet.com
Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
The emerging mechanisms and functions of microautophagy
L Wang, DJ Klionsky, HM Shen - Nature Reviews Molecular Cell …, 2023 - nature.com
Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential
MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023 - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Inflammation and immune dysfunction in Parkinson disease
MG Tansey, RL Wallings, MC Houser… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …
organs as well as the central nervous system and involves a fundamental role of …
[HTML][HTML] Fumarate induces vesicular release of mtDNA to drive innate immunity
V Zecchini, V Paupe, I Herranz-Montoya, J Janssen… - Nature, 2023 - nature.com
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
Mitochondria at the crossroads of health and disease
A Suomalainen, J Nunnari - Cell, 2024 - cell.com
Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …
life. How their structure and function are dynamically tuned in response to tissue-specific …
Mitochondrial dysfunction in aging
Y Guo, T Guan, K Shafiq, Q Yu, X Jiao, D Na, M Li… - Ageing research …, 2023 - Elsevier
Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
CL Kuo, A Ponneri Babuharisankar, YC Lin… - Journal of biomedical …, 2022 - Springer
The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …
Molecular mechanisms of mitochondrial dynamics
Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …