Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Schizophrenia is associated with substantial unmet needs, highlighting the necessity for
new treatments. This narrative review compares the pharmacology, clinical trial data and …

Duration of untreated psychosis (DUP) has been associated with poor mental health
outcomes. We aimed to meta-analytically estimate the mean and median DUP worldwide …

Objective Medical students frequently experience a range of stressors, such as demanding
academic requirements, competition and rivalry, self-doubt, and financial distress. As a …

Schizophrenia is a serious mental illness that requires continuous and effective long-term
management to reduce symptoms, improve quality of life, and prevent relapse. Oral …

Psychotic disorders affect 3% of the population at some stage in life, are a leading cause of
disability, and impose a great economic burden on society. Major breakthroughs in the …

Psychiatry shares most ethical issues with other branches of medicine, but also faces
special challenges. The Code of Ethics of the World Psychiatric Association offers guidance …

Background Early-onset psychosis (EOP) refers to the development of a first episode of
psychosis before 18 years of age. Individuals at clinical high risk for psychosis (CHR-P) …