Macrophages in health and disease
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …
increasingly transparent over the last decade. But with the plethora of data comes a natural …
Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics
Probiotics have been considered as an economical and safe alternative for the treatment of
a large number of chronic diseases and improvement of human health. They are known to …
a large number of chronic diseases and improvement of human health. They are known to …
Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis
F Cao, L **, Y Gao, Y Ding, H Wen, Z Qian… - Nature …, 2023 - nature.com
Inflammatory bowel disease can be caused by the dysfunction of the intestinal mucosal
barrier and dysregulation of gut microbiota. Traditional treatments use drugs to manage …
barrier and dysregulation of gut microbiota. Traditional treatments use drugs to manage …
Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge
of circulating immune cell types and states associated with SLE remains incomplete. We …
of circulating immune cell types and states associated with SLE remains incomplete. We …
Human microglial state dynamics in Alzheimer's disease progression
Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
Genome-wide enhancer maps link risk variants to disease genes
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …
are associated with human diseases and complex traits, each of which could reveal insights …
Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)
JJA van Kampen, DAMC van de Vijver… - Nature …, 2021 - nature.com
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …
Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues
M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …
immunological, and genetic factors. Alterations in the gut microbiota have been associated …
Epidemiology and pathogenesis of ulcerative colitis
L Du, C Ha - Gastroenterology Clinics, 2020 - gastro.theclinics.com
Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disorder of the colon
(IBD) that is hypothesized to be related to exposure to environmental risk factors leading to …
(IBD) that is hypothesized to be related to exposure to environmental risk factors leading to …
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …