The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Objective: Loss of pleasure or interest in activities (ie, anhedonia) is a risk factor for
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …

The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Brady and Kendall (1992) concluded that although anxiety and depression in youths are
meaningfully linked, there are important distinctions, and additional research is needed …

Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …

Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …

Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …

Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

Although mood disorders constitute leading causes of disability, until recently little was
known about their pathogenesis. The delineation of anatomical networks that support …