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Prefrontal cortex and depression
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
Toward a better understanding of the mechanisms and pathophysiology of anhedonia: are we ready for translation?
Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
Positive affect treatment for depression and anxiety: A randomized clinical trial for a core feature of anhedonia.
Objective: Loss of pleasure or interest in activities (ie, anhedonia) is a risk factor for
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …
Assessing anhedonia in depression: Potentials and pitfalls
The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …
A randomized proof-of-mechanism trial applying the 'fast-fail'approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …
too-often-misleading early-phase drug development methods by incorporating biomarker …
Comorbidity of anxiety and depression in children and adolescents: 20 years after.
Brady and Kendall (1992) concluded that although anxiety and depression in youths are
meaningfully linked, there are important distinctions, and additional research is needed …
meaningfully linked, there are important distinctions, and additional research is needed …
Treatment for anhedonia: A neuroscience driven approach
Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …
Rodent tests of depression and anxiety: Construct validity and translational relevance
Behavioral testing constitutes the primary method to measure the emotional states of
nonhuman animals in preclinical research. Emerging as the characteristic tool of the …
nonhuman animals in preclinical research. Emerging as the characteristic tool of the …
Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
Advances in the computational understanding of mental illness
Computational psychiatry is a rapidly growing field attempting to translate advances in
computational neuroscience and machine learning into improved outcomes for patients …
computational neuroscience and machine learning into improved outcomes for patients …