Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder
An important challenge in mental health research is to translate findings from cognitive
neuroscience and neuroimaging research into effective treatments that target the …
neuroscience and neuroimaging research into effective treatments that target the …
Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety-and depression-like behaviours
H Yu, L Chen, H Lei, G Pi, R **ong, T Jiang… - Nature …, 2022 - nature.com
Generalization is a fundamental cognitive ability of organisms to deal with the uncertainty in
real-world situations. Excessive fear generalization and impaired reward generalization are …
real-world situations. Excessive fear generalization and impaired reward generalization are …
Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway
A Vallée, Y Lecarpentier, JN Vallée - Molecular Psychiatry, 2022 - nature.com
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by
recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear …
recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear …
Acute effects of cannabinoids on symptoms of obsessive‐compulsive disorder: A human laboratory study
Background Preclinical data implicate the endocannabinoid system in the pathology
underlying obsessive‐compulsive disorder (OCD), while survey data have linked OCD …
underlying obsessive‐compulsive disorder (OCD), while survey data have linked OCD …
Avoidance of learnt fear: Models, potential mechanisms, and future directions
Avoiding stimuli that were previously associated with threat is essential for adaptive
functioning, but excessive avoidance that persists in the absence of threat can turn …
functioning, but excessive avoidance that persists in the absence of threat can turn …
Disrupted state transition learning as a computational marker of compulsivity
Background Disorders involving compulsivity, fear, and anxiety are linked to beliefs that the
world is less predictable. We lack a mechanistic explanation for how such beliefs arise …
world is less predictable. We lack a mechanistic explanation for how such beliefs arise …
Increased attention allocation to stimuli reflecting end-states of compulsive behaviors among obsessive compulsive individuals
Attentional research in OCD has focused solely on threat stimuli, assumed to provoke
related obsessions and ensuing compulsions. OCD-related stimuli depicting the completion …
related obsessions and ensuing compulsions. OCD-related stimuli depicting the completion …
Humans display interindividual differences in the latent mechanisms underlying fear generalization behaviour
Human generalization research aims to understand the processes underlying the transfer of
prior experiences to new contexts. Generalization research predominantly relies on …
prior experiences to new contexts. Generalization research predominantly relies on …
WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder
A Vallée, Y Lecarpentier, JN Vallée - Neural Regeneration …, 2022 - journals.lww.com
The neuropsychiatric disease named obsessive-compulsive disorder is composed by
obsessions and/or compulsions. Obsessive-compulsive disorder etiologies are undefined …
obsessions and/or compulsions. Obsessive-compulsive disorder etiologies are undefined …
[HTML][HTML] Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.
L Pellegrini, NA Fineberg - Neuroscience Applied, 2024 - Elsevier
The ability to flexibly adapt thoughts and behaviours represents a fundamental attribute for
behavioural success. Impairments in aspects of cognitive flexibility are found as …
behavioural success. Impairments in aspects of cognitive flexibility are found as …