Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Abstract Treatment of acute myocardial infarction (AMI) has improved significantly in recent
years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive …

Inflammation resolution is important for scar formation following myocardial infarction (MI)
and requires the coordinated actions of macrophages and fibroblasts. In this study, we …

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …

Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells
and matrix debris, while activating reparative pathways necessary for scar formation. A …

In the infarcted heart, the damage‐associated molecular pattern proteins released by
necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of …

Mounting evidence suggests that therapeutic cell and drug delivery strategies designed to
actively harness the regenerative potential of the inflammatory response have great …