The regulation and utilization of thermal energy is increasingly important in modern society
due to the growing demand for heating and cooling in applications ranging from buildings, to …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Nociceptors are a subset of small primary afferent neurons that respond to noxious
chemical, thermal and mechanical stimuli. Ion channels in nociceptors respond differently to …

TRPA1 functions as an excitatory ionotropic receptor in sensory neurons. It was originally
described as a noxious cold-activated channel, but its cold sensitivity has been disputed in …

The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …

Migraine afflicts more than 10% of the general population. Although its mechanism is poorly
understood, recent preclinical and clinical evidence has identified calcitonin gene related …