[HTML][HTML] A series of isatin-hydrazones with cytotoxic activity and CDK2 kinase inhibitory activity: a potential type II ATP competitive inhibitor

HS Al-Salem, M Arifuzzaman, HM Alkahtani… - Molecules, 2020 - mdpi.com
Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …

Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications

A Alam, FU Rahman, AA Elhenawy, A Ali… - Mini-Reviews in …, 2025 - benthamdirect.com
Organic compounds containing azines, di-imines, or bis-Schiff-bases have two azomethine (-
CH= N-) functional groups associated with a bridging component. These constituents have …

Synthesis of a New Series of N‐Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases

EM Afsah, AA Fadda, AH Hanash - Journal of Heterocyclic …, 2018 - Wiley Online Library
The reaction of isatin 1 with benzaldehyde and a sec‐amine or the appropriate aldimine
afforded the N‐Mannich bases 2–3 and the bis‐base 4. Treatment of 1 with glutaric …

Synthesis and biological activity evaluation of some new mixed azines appended tetrahydro-1, 2, 4-triazines

E Abdel-Galil, AM Arab, EM Afsah - Synthetic Communications, 2021 - Taylor & Francis
Abstract A series of 6-acetyl-2, 4-diaryl-2, 3, 4, 5-tetrahydro-1, 2, 4-triazines (2a–2f) was
synthesized by double Mannich reaction of the hydrazone 1a or 1b with formaldehyde and …

Isatin Aldazines Synthesis using A Proton Exchanged Algerian Montmorillonite Clay as Acid Eco-friendly Catalyst

B Benlahreche, A Taleb, MB Lahrech… - Bulletin of Chemical …, 2019 - journal.bcrec.id
An efficient and easy procedure is developed for the synthesis of isatin aldazines or bis-
Schiff bases of isatin, catalyzed by a proton exchanged Algerian montmorillonite clay (MMT …

Synthesis of some new hydrazide-hydrazones related to isatin and its Mannich and Schiff bases

EM Afsah, SS Elmorsy, SM Abdelmageed… - … für Naturforschung B, 2016 - degruyter.com
The hydrazide-hydrazones 6a–d and 7a, b were obtained by treating isatin (1) or its
Mannich base 2 with hydrazides incorporating piperidine, morpholine, and piperazine units …

Novel one‐pot synthesis of imidazo[2,1‐b] [1, 2, 4]‐Triazoles, 1,2,4‐Triazolo iminoindoline‐2‐ones, and their in‐vitro antibacterial activity, B‐DNA study

P Venkatesham, SR Parcha, SL Rath… - Journal of …, 2023 - Wiley Online Library
Abstract New series of 2‐(benzylthio)‐6‐phenyl‐4 H‐imidazo [1, 2‐b][1, 2, 4]‐Triazoles and
benzylthio‐4 H‐1, 2, 4‐Triazolo iminoimdoline‐2‐ones have been synthesized via a one …

Crystal structures and Hirshfeld surface analysis of four 1, 4-bis (methoxyphenyl)-2, 3-diazabuta-1, 3-dienes: comparisons of the intermolecular interactions in related …

LR Gomes, JN Low, NRL Correira… - Zeitschrift für …, 2019 - degruyter.com
The crystal structures of four azines, namely 1-3-bis (4-methoxyphenyl)-2, 3-diaza-1, 4-
butadiene, 1, 1, 3-bis (2, 3-dimethoxyphenyl)-2, 3-diaza-1, 4-butadiene, 2, 1, 3-bis (2 …

Mannich Reaction with Enaminones: Convenient Synthesis of Functionalized Tetrahydro‐pyrimidines, Dihydro‐1, 3‐oxazines, and Dihydro‐1, 2, 4‐triazepines

EM Afsah, ESI El‐Desoky, HA Etman… - Journal of …, 2018 - Wiley Online Library
A series of tetrahydropyrimidines and bis‐(tetrahydropyrimidines) was synthesized by
Mannich reaction of sec‐emaminones with formaldehyde and the appropriate amine or …

Учредители: Уфимский государственный нефтяной технический университет, Башкирский государственный университет, Башкирский государственный …

ЭГ Мамедбейли, ИГ Аюбов, СВ Исмайылова… - Башкирский …, 2022 - elibrary.ru
Представлен обзор результатов научных исследований в области синтеза и изучения
биологически активных свойств пиперидинсодержащих оснований Манниха …