Therapeutic interventions after spinal cord injury
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …
Pathophysiology of spastic paresis. I: Paresis and soft tissue changes
JM Gracies - Muscle & Nerve: Official Journal of the American …, 2005 - Wiley Online Library
Spastic paresis follows chronic disruption of the central execution of volitional command.
Motor function in patients with spastic paresis is subjected over time to three fundamental …
Motor function in patients with spastic paresis is subjected over time to three fundamental …
Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans
Previously, we reported that one individual who had a motor complete, but sensory
incomplete spinal cord injury regained voluntary movement after 7 months of epidural …
incomplete spinal cord injury regained voluntary movement after 7 months of epidural …
Pathophysiology of spastic paresis. II: Emergence of muscle overactivity
JM Gracies - Muscle & Nerve: Official Journal of the American …, 2005 - Wiley Online Library
In the subacute and chronic stages of spastic paresis, stretch‐sensitive (spastic) muscle
overactivity emerges as a third fundamental mechanism of motor impairment, along with …
overactivity emerges as a third fundamental mechanism of motor impairment, along with …
Motor recovery after activity-based training with spinal cord epidural stimulation in a chronic motor complete paraplegic
E Rejc, CA Angeli, D Atkinson, SJ Harkema - Scientific reports, 2017 - nature.com
The prognosis for recovery of motor function in motor complete spinal cord injured (SCI)
individuals is poor. Our research team has demonstrated that lumbosacral spinal cord …
individuals is poor. Our research team has demonstrated that lumbosacral spinal cord …
Spinal cord repair strategies: why do they work?
There are now numerous preclinical reports of various experimental treatments promoting
some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that …
some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that …
Recovery from a spinal cord injury: significance of compensation, neural plasticity, and repair
Clinical recovery after a lesion of the central nervous system (CNS) can be attributed to
mechanisms of functional compensation, neural plasticity, and/or repair. The relative impact …
mechanisms of functional compensation, neural plasticity, and/or repair. The relative impact …
Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays
FM Bareyre, ME Schwab - Trends in neurosciences, 2003 - cell.com
GeneChip® microarrays have recently been introduced to the field of neurobiology to
identify and monitor the expression levels of thousands of genes simultaneously. This …
identify and monitor the expression levels of thousands of genes simultaneously. This …
Spinal cord injury: time to move?
This symposium aims at summarizing some of the scientific bases for current or planned
clinical trials in patients with spinal cord injury (SCI). It stems from the interactions of four …
clinical trials in patients with spinal cord injury (SCI). It stems from the interactions of four …
The fate and function of oligodendrocyte progenitor cells after traumatic spinal cord injury
Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …