The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

The appearance and prevalence of multidrug-resistance (MDR) Gram-negative bacteria
(GNB) have limited our antibiotic capacity to control bacterial infections. The clinical efficacy …

In Gram-negative bacteria, the permeability of the outer membrane governs rates of
antibiotic uptake and thus the efficacy of antimicrobial treatment. Hydrophilic drugs like β …

Antibiotics are the super drugs that have revolutionized modern medicine by curing many
infectious diseases caused by various microbes. They efficiently inhibit the growth and …

Antibiotic resistance is increasingly becoming a challenge to public health. The regulation of
bacterial metabolism by post-translational modifications (PTMs) has been widely studied …

The prevalence of extensively and pandrug-resistant strains of Acinetobacter baumannii
leaves little or no therapeutic options for treatment for this bacterial pathogen …

Methicillin-resistant Staphylococcus aureus (MRSA) strains are tolerant of conventional
antibiotics, making them extremely dangerous. Previous studies have shown the …

The emergence of a transferable colistin resistance gene (mcr-1) is of global concern. The
insertion sequence IS Apl1 is a key component in the mobilization of this gene, but its role …