Proteins play a crucial role in organisms in nature. They are able to perform structural,
catalytic, transport and defense functions in cells, among others. We understand that a …

Elucidating the biological and biochemical roles of proteins, and subsequently determining
their interacting partners, can be difficult and time consuming using in vitro and/or in vivo …

Determining the catalytic residues in an enzyme is critical to our understanding the
relationship between protein sequence, structure, function, and enhancing our ability to …

In recent time, data analysis using machine learning accelerates optimized solutions on
clinical healthcare systems. The machine learning methods greatly offer an efficient …

Motivation Accurate annotation of protein functions is fundamental for understanding
molecular and cellular physiology. Data-driven methods hold promise for systematically …

Abstract Motivation Hematopoietic stem cells (HSCs) give rise to all blood cells and play a
vital role throughout the whole lifespan through their pluripotency and self-renewal …

Background The correct determination of protein–protein interaction interfaces is important
for understanding disease mechanisms and for rational drug design. To date, several …

Motivation The discovery of protein–ligand-binding sites is a major step for elucidating
protein function and for investigating new functional roles. Detecting protein–ligand-binding …

In the current “genomic era” the number of identified genes is growing exponentially.
However, the biological function of a large number of the corresponding proteins is still …

Enzyme active sites are important and conserved functional regions of proteins whose
identification can be an invaluable step toward protein function prediction. Most of the …